Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8016347 | 0.95 | TLR8 (0.47) | TLR8GSK3BHRH3HRH2RAB9A | |
| SCHEMBL8012754 | 0.90 | SREBF2 (0.41) | TLR8GSK3BHRH3HRH2RAB9A | |
| SCHEMBL13277717 | 0.84 | GSK3B (0.43) | TLR8GSK3BRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL22585763 | 0.84 | RAD52 (0.44) | TLR8RAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL6618330 | 0.84 | GSK3B (0.44) | TLR8GSK3BRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8012285 | 0.83 | TLR8 (0.39) | TLR8RAB9ASMN1; SMN2NPC1TP53 | |
| Ammonia Solution, Strong SCHEMBL27564785 | 0.83 | GSK3B (0.43) | TLR8GSK3BRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4943588 | 0.80 | GAA (0.37) | TLR8RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL6129194 | 0.80 | TLR8 (0.45) | TLR8GSK3BHRH3RAB9ANPC1 | |
| SCHEMBL17626094 | 0.79 | GSK3B (0.41) | GSK3BRAB9ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |