Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SPNS2 | Q8IVW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8012182 | 0.95 | TLR8 (0.44) | TLR8MAPTKDM4ERAB9AMEN1 | |
| SCHEMBL8012754 | 0.89 | SREBF2 (0.41) | TLR8MAPTKDM4ERAB9AMEN1 | |
| SCHEMBL4814536 | 0.84 | GPR84 (0.42) | TLR8MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL11297462 | 0.83 | GPR84 (0.44) | TLR8MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL22585763 | 0.83 | RAD52 (0.44) | TLR8MAPTKDM4ERAB9AMEN1 | |
| SCHEMBL2946753 | 0.83 | GPR84 (0.44) | TLR8MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL8012285 | 0.82 | TLR8 (0.39) | TLR8MAPTKDM4ERAB9AMEN1 | |
| SCHEMBL13277717 | 0.80 | GSK3B (0.43) | TLR8RAB9AALDH1A1SMN1; SMN2GSK3B | |
| SCHEMBL6618330 | 0.80 | GSK3B (0.44) | TLR8MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4812369 | 0.79 | XDH (0.40) | MAPTKDM4ERAB9AMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |