Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.49 |
| ▸ | RAB9A | P51151 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8012581 | 1.00 | NPC1 (0.49) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8012113 | 0.92 | NOTUM (0.44) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8012108 | 0.92 | NOTUM (0.44) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8017042 | 0.86 | NPC1 (0.43) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3943285 | 0.84 | NPC1 (0.43) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3943289 | 0.83 | SLC2A1 (0.42) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3943293 | 0.83 | SLC2A1 (0.42) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8013043 | 0.81 | LMNA (0.39) | MAPTLMNA | |
| SCHEMBL8013046 | 0.81 | LMNA (0.39) | MAPTLMNA | |
| SCHEMBL8000525 | 0.79 | EGFR (0.42) | ALDH1A1SMN1; SMN2NOTUML3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |