Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8007637 | 0.84 | GRIN1 (0.58) | GRIN1GRIN2BRAB9AMAPTENPP2 | |
| SCHEMBL12576523 | 0.79 | GRIN1 (0.57) | GRIN1GRIN2BRAB9AMAPTENPP2 | |
| SCHEMBL2022580 | 0.79 | GRIN1 (0.59) | GRIN1GRIN2BRAB9AMAPTENPP2 | |
| SCHEMBL2018529 | 0.78 | GRIN1 (0.58) | GRIN1GRIN2BRAB9AMAPTENPP2 | |
| SCHEMBL8006950 | 0.77 | GRIN1 (0.70) | GRIN1GRIN2BRAB9AMAPTENPP2 | |
| SCHEMBL12576407 | 0.76 | GRIN1 (0.72) | GRIN1GRIN2BRAB9AMAPTENPP2 | |
| SCHEMBL8008982 | 0.76 | GRIN1 (0.58) | GRIN1GRIN2BRAB9AMAPTENPP2 | |
| SCHEMBL7997522 | 0.76 | GRIN1 (0.60) | GRIN1GRIN2BRAB9AMAPTENPP2 | |
| SCHEMBL2016624 | 0.74 | GRIN1 (0.55) | GRIN1GRIN2BRAB9AMAPTENPP2 | |
| SCHEMBL12575492 | 0.74 | GRIN1 (0.77) | GRIN1GRIN2BRAB9AMAPTENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170334-B1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | UNIV EMORY (US) | 2021-03-17 | — | — | EP | disclosed |
| WO-2009137843-A2 | NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | EMORY UNIVERSITY (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009006437-A1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | EMORY UNIVERSITY (US) | 2009-01-08 | — | — | WO | disclosed |