Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 2/20 | 0.72 |
| ▸ | CTSK | P43235 | 9/20 | 0.70 |
| ▸ | CTSL | P07711 | 6/20 | 0.70 |
| ▸ | MMP1 | P03956 | 1/20 | 0.68 |
| ▸ | MMP2 | P08253 | 1/20 | 0.68 |
| ▸ | MMP3 | P08254 | 1/20 | 0.68 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.66 |
| ▸ | CTSB | P07858 | 3/20 | 0.65 |
| ▸ | CTSS | P25774 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13888706 | 0.93 | CTSK (0.79) | CTSKCTSLCTSBCTSS | |
| SCHEMBL1175268 | 0.93 | CTSK (0.79) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6945614 | 0.93 | CTSK (0.79) | CTSKCTSLCTSBCTSS | |
| SCHEMBL10975356 | 0.92 | CAPN1 (0.73) | CAPN1CTSKCTSLMMP1MMP2 | |
| SCHEMBL7327426 | 0.91 | CAPN1 (0.78) | CAPN1CTSKCTSLHTRA1CTSB | |
| SCHEMBL21219280 | 0.91 | CAPN1 (0.74) | CAPN1CTSKCTSLHTRA1CTSB | |
| SCHEMBL9831181 | 0.91 | CAPN1 (0.74) | CAPN1CTSKCTSLHTRA1CTSB | |
| SCHEMBL21219352 | 0.91 | CAPN1 (0.74) | CAPN1CTSKCTSLHTRA1CTSB | |
| SCHEMBL29483597 | 0.91 | CAPN1 (0.74) | CAPN1CTSKCTSLHTRA1CTSB | |
| SCHEMBL21219351 | 0.91 | CAPN1 (0.74) | CAPN1CTSKCTSLHTRA1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728144-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | DARWIN DISCOVERY LTD (GB) | 2000-01-19 | — | — | EP | disclosed |
| US-5853623-A | Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases | CHIROSCIENCE LIMITED (GB) | 1998-12-29 | — | — | US | disclosed |