Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.47 |
| ▸ | PPARA | Q07869 | 9/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 5/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23117326 | 0.93 | PPARG (0.53) | PPARGPPARACYP2C9CYP1A2CYP2C19 | |
| SCHEMBL7757488 | 0.93 | PPARG (0.53) | PPARGPPARACYP2C9CYP1A2CYP2C19 | |
| SCHEMBL8015241 | 0.91 | PPARG (0.49) | PPARGPPARACYP2C9CYP1A2CYP2C19 | |
| SCHEMBL7430468 | 0.88 | PPARG (0.55) | PPARGPPARACYP2C9CYP1A2CYP2C19 | |
| SCHEMBL7762822 | 0.85 | GMNN (0.39) | CYP2C9MAPTGMNNTP53POLB | |
| SCHEMBL21153885 | 0.82 | PPARA (0.57) | PPARGPPARACYP2C9CYP1A2CYP2C19 | |
| SCHEMBL6484104 | 0.82 | PPARA (0.57) | PPARGPPARACYP2C9CYP1A2CYP2C19 | |
| SCHEMBL13855559 | 0.82 | CTSK (0.47) | PPARGPPARACYP2C9CYP1A2CYP2C19 | |
| SCHEMBL7763906 | 0.81 | CES1 (0.46) | CYP2C9MAPTGMNNTP53POLB | |
| SCHEMBL15703381 | 0.80 | CYP1A2 (0.50) | PPARGPPARACYP2C9CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015877-A | ANTICARCINOGENIC AGENT WHICH INHIBITS ENDOPROTEASE ACTIVITY DIRECTED AGAINST SPECIFIC CYSTEINE CONTAINING CARBOXY TERMINAL MOTIF FOUND IN RAS PROTEINS AND OTHER SIGNAL TRANSDUCING G PROTEINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-01-18 | — | — | US | claimed |