Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.62 |
| ▸ | SLC1A2 | P43004 | 7/20 | 0.56 |
| ▸ | SLC1A1 | P43005 | 7/20 | 0.56 |
| ▸ | SLC1A3 | P43003 | 6/20 | 0.56 |
| ▸ | GRIK1 | P39086 | 9/20 | 0.47 |
| ▸ | GRIK2 | Q13002 | 7/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | BHMT | Q93088 | 1/20 | 0.42 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2422005 | 1.00 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL2422006 | 1.00 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL3514273 | 1.00 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| Hydrochloric Acid SCHEMBL8663720 | 0.98 | SLC7A5 (0.60) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| Hydrochloric Acid SCHEMBL6954433 | 0.98 | SLC7A5 (0.60) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL7460997 | 0.84 | SLC7A5 (0.60) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL2420111 | 0.82 | SLC7A5 (0.58) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL6138683 | 0.82 | SLC7A5 (0.58) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL199134 | 0.82 | SLC7A5 (0.58) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL8015716 | 0.82 | SLC7A5 (0.58) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127420-A | SELECTIVE, IRREVERSIBLE INHIBITORS OF NEURONAL ISOFORM OF NITRIC OXIDE SYNTHASE PRODUCING NITRIC OXIDE; MIGRAINE HEADACHES, STROKE, PAIN INCLUDING CHRONIC VISCERAL PAIN, DRUG ADDICTION, PARKINSON'S DISEASE, SCHIZOPHRENIA, ANTIEPILEPTIC | THE MEDICAL COLLEGE OF WISCONSIN RESEARCH FOUNDATION, INC. (US) | 2000-10-03 | — | — | US | disclosed |