SCHEMBL8015669

SCHEMBL8015669

CCCc1ccc(-c2ccc(C(=O)O)cc2)c(-c2cc(F)c(F)c(F)c2)c1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RARB P10826 10/20 0.54
MPL P40238 3/20 0.48
NPC1 O15118 1/20 0.47
TP53 P04637 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
RARA P10276 2/20 0.45
ALDH1A1 P00352 2/20 0.45
MEN1 O00255 1/20 0.45
MAPT P10636 1/20 0.45
MTOR P42345 1/20 0.45
KMT2A Q03164 1/20 0.45
FOLH1 Q04609 1/20 0.43
RARG P13631 1/20 0.42
RXRA P19793 1/20 0.41
RXRB P28702 1/20 0.41
KDM4E B2RXH2 1/20 0.41
LMNA P02545 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8025917 0.93 RARB (0.61) RARBMPLNPC1RAB9ASMN1; SMN2
SCHEMBL8015665 0.92 RARB (0.60) RARBMPLNPC1TP53RAB9A
SCHEMBL8025725 0.91 RARB (0.67) RARBMPLNPC1RAB9ASMN1; SMN2
SCHEMBL15797758 0.85 RARB (0.67) RARBMPLNPC1TP53RAB9A
SCHEMBL8025915 0.85 RARB (0.68) RARBMPLRARAALDH1A1MEN1
SCHEMBL8025722 0.84 RARB (0.74) RARBMPLNPC1RAB9ASMN1; SMN2
SCHEMBL17108401 0.83 RARB (0.68) RARBMPLNPC1TP53RAB9A
SCHEMBL7730650 0.81 RARB (0.55) RARBMPLRARARARG
SCHEMBL28548977 0.80 RARB (0.80) RARBMPLNPC1TP53RAB9A
SCHEMBL9639828 0.78 RARB (0.76) RARBMPLNPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0704512-B1 A liquid crystal composition and a liquid crystal display element using the same CHISSO CORP (JP) 2000-03-08 EP disclosed
EP-0704512-A1 A liquid crystal composition and a liquid crystal display element using the same Chisso Corporation (JP) 1996-04-03 EP disclosed