SCHEMBL8015684

SCHEMBL8015684

COC=C(C(=O)O)c1ccccc1COc1cccc(N=Cc2ccccc2)c1

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 6/20 0.47
SPHK2 Q9NRA0 4/20 0.41
SPHK1 Q9NYA1 3/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7173684 0.92 HIF1A (0.52) HIF1ASPHK2SPHK1CA1CA2
SCHEMBL7173685 0.92 HIF1A (0.52) HIF1ASPHK2SPHK1CA1CA2
SCHEMBL7628478 0.82 HIF1A (0.57) HIF1A
SCHEMBL8639304 0.82 KDM4E (0.47) HIF1A
SCHEMBL28681565 0.78 HIF1A (0.43) HIF1AKMT2A
SCHEMBL28684364 0.78 PARP10 (0.43) HIF1AMEN1KMT2A
SCHEMBL8083999 0.76 HIF1A (0.41) HIF1A
SCHEMBL8083996 0.76 HIF1A (0.41) HIF1A
SCHEMBL9894571 0.76 HIF1A (0.62) HIF1ASPHK2SPHK1
SCHEMBL9894570 0.76 HIF1A (0.62) HIF1ASPHK2SPHK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0278595-B2 Fungicides ZENECA LTD (GB) 2000-01-12 EP disclosed
EP-0472224-B1 Fungicides ZENECA LTD (GB) 1994-04-27 EP disclosed
EP-0472224-A1 Fungicides ZENECA LIMITED (GB) 1992-02-26 EP disclosed