Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018407 | 1.00 | TDP1 (0.53) | TDP1MAPK1CES1CA1CA2 | |
| SCHEMBL8007718 | 0.81 | MAPT (0.50) | MAPK1CES1CA1CA2POLB | |
| SCHEMBL8007714 | 0.81 | MAPT (0.50) | MAPK1CES1CA1CA2POLB | |
| SCHEMBL8017795 | 0.80 | TDP1 (0.60) | TDP1MAPK1CES1CA1CA2 | |
| SCHEMBL8017793 | 0.80 | TDP1 (0.60) | TDP1MAPK1CES1CA1CA2 | |
| SCHEMBL10442166 | 0.79 | TDP1 (0.44) | TDP1MAPK1CES1CA1CA2 | |
| SCHEMBL10022020 | 0.78 | MAPK1 (0.56) | TDP1MAPK1CES1CA1CA2 | |
| SCHEMBL9658209 | 0.78 | TPMT (0.46) | MAPK1CA1CA2TSHRALDH1A1 | |
| SCHEMBL9658211 | 0.78 | TPMT (0.46) | MAPK1CA1CA2TSHRALDH1A1 | |
| SCHEMBL9659486 | 0.78 | CA1 (0.48) | TDP1MAPK1CA1CA2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675133-B1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO CO (JP) | 2000-01-12 | — | — | EP | disclosed |
| US-5614470-A | AGRICULTURAL ANTHELMINTIC, ACARICIDE, INSECTICIDE | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0675133-A1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1995-10-04 | — | — | EP | disclosed |