Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8007718 | 1.00 | MAPT (0.50) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL10442022 | 0.86 | MAPT (0.52) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL28845740 | 0.82 | SMN1; SMN2 (0.47) | KMT2AMEN1ALDH1A1GAALMNA | |
| SCHEMBL10441814 | 0.81 | KCNJ1 (0.45) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL8018403 | 0.81 | TDP1 (0.53) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8018407 | 0.81 | TDP1 (0.53) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6152764 | 0.79 | SMN1; SMN2 (0.61) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8018548 | 0.79 | SMN1; SMN2 (0.61) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL478613 | 0.79 | CES1 (0.61) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL21283556 | 0.77 | MAPT (0.56) | MAPTKMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675133-B1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO CO (JP) | 2000-01-12 | — | — | EP | disclosed |
| US-5614470-A | AGRICULTURAL ANTHELMINTIC, ACARICIDE, INSECTICIDE | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0675133-A1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1995-10-04 | — | — | EP | disclosed |