Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 4/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480706 | 1.00 | MDM4 (0.46) | MDM4TP53CASP3PIN1KMT2A | |
| SCHEMBL31000753 | 1.00 | MDM4 (0.46) | MDM4TP53CASP3PIN1KMT2A | |
| SCHEMBL5913024 | 1.00 | MDM4 (0.46) | MDM4TP53CASP3PIN1KMT2A | |
| SCHEMBL31000751 | 1.00 | MDM4 (0.46) | MDM4TP53CASP3PIN1KMT2A | |
| SCHEMBL6481998 | 1.00 | MDM4 (0.46) | MDM4TP53CASP3PIN1KMT2A | |
| SCHEMBL31000614 | 0.87 | CASP3 (0.43) | MDM4TP53CASP3PIN1KMT2A | |
| SCHEMBL31000582 | 0.87 | FFAR1 (0.43) | MDM4TP53CASP3PIN1MDM2 | |
| SCHEMBL31000535 | 0.85 | HDAC3 (0.43) | MDM4TP53CASP3PIN1KMT2A | |
| SCHEMBL31000490 | 0.85 | MDM4 (0.43) | MDM4TP53CASP3PIN1MDM2 | |
| SCHEMBL6225058 | 0.84 | TACR1 (0.44) | PIN1KMT2AMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063796-A | HETEROCYCLIC COMPOUNDS OF PIPERIDINE | MERCK & CO., INC. (US) | 2000-05-16 | — | — | US | disclosed |
| US-6057338-A | USEFUL IN THE TREATMENT OF DIABETES, CANCER, ACROMEGALY, RESTENOSIS, DEPRESSION, IRRITABLE BOWEL SYNDROME, PAIN AND DIABETIC RETINOPATHY | MERCK & CO., INC. (US) | 2000-05-02 | — | — | US | disclosed |