SCHEMBL8018737

SCHEMBL8018737

[CH2]C1CC(=O)NC(=O)N1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19973973 0.81
SCHEMBL815291 0.70
SCHEMBL6011630 0.70
SCHEMBL21731425 0.70
SCHEMBL8285795 0.70
SCHEMBL13033027 0.70
SCHEMBL1774204 0.70
SCHEMBL5433985 0.70
SCHEMBL8195841 0.69 CRBN (0.33)
SCHEMBL6042160 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-7082166-A None JP disclosed
US-20220177521-A1 PROCESS FOR THE PREPARATION OF DEGARELIX Fresenius Kabi Ipsum S.R.L. (IT) 2022-06-09 US disclosed
EP-3981781-A1 PROCESS FOR THE MANUFACTURE OF DEGARELIX AND ITS INTERMEDIATES Fresenius Kabi iPSUM S.r.l. (IT) 2022-04-13 EP disclosed
CN-108779150-B Preparation method of degarelix and intermediate thereof 费森尤斯卡比依普莎姆责任有限公司 2022-03-29 CN disclosed
US-20220033443-A1 PROCESS FOR THE MANUFACTURE OF DEGARELIX AND ITS INTERMEDIATES Fresenius Kabi iPSUM S.r.l (IT) 2022-02-03 US disclosed
EP-3935072-A1 PROCESS FOR THE PREPARATION OF DEGARELIX Fresenius Kabi iPSUM S.r.l. (IT) 2022-01-12 EP disclosed
US-11168114-B2 Process for the manufacture of degarelix and its intermediates Fresenius Kabi iPSUM S.r.l (IT) 2021-11-09 US disclosed
US-20200172577-A9 PROCESS FOR THE MANUFACTURE OF DEGARELIX AND ITS INTERMEDIATES Fresenius Kabi Ipsum S.R.L. (IT) 2020-06-04 US disclosed
US-20180362588-A1 PROCESS FOR THE MANUFACTURE OF DEGARELIX AND ITS INTERMEDIATES FRESENIUS KABI IPSUM S R L (IT) 2018-12-20 US disclosed
EP-3390427-A1 PROCESS FOR THE MANUFACTURE OF DEGARELIX AND ITS INTERMEDIATES Fresenius Kabi iPSUM S.r.l. (IT) 2018-10-24 EP disclosed
WO-2017103275-A1 PROCESS FOR THE MANUFACTURE OF DEGARELIX AND ITS INTERMEDIATES FRESENIUS KABI ANTI-INFECTIVES S.R.L (IT) 2017-06-22 WO disclosed
EP-1003774-A1 GnRH ANTAGONISTS BEING MODIFIED IN POSITIONS 5 AND 6 FERRING B.V. (NL) 2000-05-31 EP disclosed
EP-0973801-A1 GnRH ANTAGONISTS FERRING B.V. (NL) 2000-01-26 EP disclosed
WO-1998046635-A1 GnRH ANTAGONISTS FERRING BV (NL) 1998-10-22 WO disclosed
WO-1998046634-A1 GnRH ANTAGONISTS BEING MODIFIED IN POSITIONS 5 AND 6 FERRING B.V. (NL) 1998-10-22 WO disclosed
JP-H0782166-A ANTISHOCK AGENT TANABE SEIYAKU CO LTD 1995-03-28 JP disclosed
EP-0470175-A1 ENZYMATIC MEMBRANE METHOD FOR THE SYNTHESIS AND SEPARATION OF PEPTIDES THE COCA-COLA COMPANY (US) 1992-02-12 EP disclosed