Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | APAF1 | O14727 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.73 |
| ▸ | FDPS | P14324 | 15/20 | 0.39 |
| ▸ | PON1 | P27169 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL36719 | 0.96 | MEN1 (0.79) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Hydrochloric Acid SCHEMBL5317022 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Hydrochloric Acid SCHEMBL28926225 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Hydrochloric Acid SCHEMBL30502416 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Hydrochloric Acid SCHEMBL7266903 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| SCHEMBL34969 | 0.94 | MEN1 (0.81) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Bromide SCHEMBL28284894 | 0.92 | SMN1; SMN2 (0.79) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Hydrochloric Acid SCHEMBL30662171 | 0.92 | MEN1 (0.73) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| SCHEMBL14841603 | 0.92 | MEN1 (0.79) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Hydrochloric Acid SCHEMBL20957483 | 0.92 | MEN1 (0.79) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000040673-A1 | INDUSTRIAL PROCESS AND CATALYSTS | THE SECRETARY OF STATE FOR DEFENCE (GB) | 2000-07-13 | — | — | WO | disclosed |