Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.78 |
| ▸ | HTR1B | P28222 | 3/20 | 0.78 |
| ▸ | HTR1D | P28221 | 1/20 | 0.78 |
| ▸ | DRD2 | P14416 | 2/20 | 0.71 |
| ▸ | DRD4 | P21917 | 1/20 | 0.71 |
| ▸ | HTR1E | P28566 | 1/20 | 0.71 |
| ▸ | HTR7 | P34969 | 1/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.71 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018888 | 1.00 | HTR1A (0.78) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL7657721 | 0.90 | HTR1A (0.62) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL7743816 | 0.88 | HTR1A (0.60) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL9265318 | 0.88 | HTR1A (0.60) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL2359786 | 0.88 | HTR1A (0.60) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| Frovatriptan SCHEMBL2456983 | 0.87 | HTR1B (1.00) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| Frovatriptan SCHEMBL34410 | 0.87 | HTR1B (1.00) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| Frovatriptan SCHEMBL16365906 | 0.87 | HTR1B (1.00) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| Frovatriptan SCHEMBL29360449 | 0.87 | HTR1B (1.00) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL6952624 | 0.87 | HTR1A (0.59) | HTR1AHTR1BHTR1DDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0969842-A1 | PHARMACEUTICAL COMPOSITION | R.P. Scherer Limited (GB) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998042344-A1 | PHARMACEUTICAL COMPOSITION | R. P. SCHERER LIMITED (GB) | 1998-10-01 | — | — | WO | disclosed |