SCHEMBL8019090

SCHEMBL8019090

Cc1nc2cc(NC(=O)c3ccco3)ccc2o1

nearest known ligand 0.69

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 12/20 0.69
NPC1 O15118 10/20 0.69
SMN1; SMN2 Q16637 8/20 0.69
KDM4E B2RXH2 7/20 0.69
HPGD P15428 3/20 0.69
ALDH1A1 P00352 6/20 0.67
MAPT P10636 7/20 0.67
POLB P06746 2/20 0.67
TDP1 Q9NUW8 1/20 0.67
TP53 P04637 4/20 0.64
MAPK1 P28482 1/20 0.64
PKM P14618 2/20 0.60
STAT1 P42224 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
HSD17B10 Q99714 2/20 0.59
MEN1 O00255 1/20 0.57
KMT2A Q03164 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2246978 0.84 RAB9A (0.82) RAB9ANPC1SMN1; SMN2KDM4EHPGD
SCHEMBL2242570 0.82 RAB9A (1.00) RAB9ANPC1SMN1; SMN2KDM4EHPGD
SCHEMBL2244458 0.79 KDM4E (0.82) RAB9ANPC1SMN1; SMN2KDM4EHPGD
SCHEMBL2243578 0.79 NPC1 (0.82) RAB9ANPC1SMN1; SMN2KDM4EHPGD
SCHEMBL2244913 0.79 RAB9A (0.77) RAB9ANPC1SMN1; SMN2KDM4EHPGD
SCHEMBL14825091 0.78 MAPT (0.77) RAB9ANPC1SMN1; SMN2KDM4EHPGD
SCHEMBL2490209 0.78 RAB9A (0.72) RAB9ANPC1SMN1; SMN2KDM4EHPGD
SCHEMBL2246906 0.78 MAPT (1.00) RAB9ANPC1SMN1; SMN2KDM4EHPGD
SCHEMBL9292313 0.78 RAB9A (0.60) RAB9ANPC1SMN1; SMN2KDM4EHPGD
SCHEMBL2246514 0.77 POLB (0.77) RAB9ANPC1SMN1; SMN2KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0599384-B1 Dye compounds and photographic elements containing such dyes EASTMAN KODAK CO (US) 2000-01-19 EP disclosed
EP-0599381-B1 Dye compounds and silver halide photographic elements containing such dyes EASTMAN KODAK CO (US) 2000-01-19 EP disclosed
US-5492802-A SENSITIZING CYANINE DYE EASTMAN KODAK COMPANY (US) 1996-02-20 US disclosed
EP-0599381-A1 Dye compounds and silver halide photographic elements containing such dyes EASTMAN KODAK COMPANY (US) 1994-06-01 EP disclosed
EP-0599384-A1 Dye compounds and photographic elements containing such dyes EASTMAN KODAK COMPANY (US) 1994-06-01 EP disclosed
US-5316904-A Cationic cyanine sensitizers in color photography EASTMAN KODAK COMPANY (US) 1994-05-31 US disclosed