Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.47 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.47 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18257113 | 0.87 | KDM4E (0.51) | SMN1; SMN2NPC1GAARAB9AKDM4E | |
| SCHEMBL8757522 | 0.86 | GLA (0.67) | SMN1; SMN2KMT2AGLATAAR1NPC1 | |
| SCHEMBL29481026 | 0.86 | GAA (0.50) | SMN1; SMN2TAAR1NPC1GAARAB9A | |
| SCHEMBL3661534 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2KMT2AGLATAAR1NPC1 | |
| SCHEMBL3656770 | 0.82 | SMN1; SMN2 (0.63) | SMN1; SMN2KMT2AGLATAAR1NPC1 | |
| SCHEMBL10266158 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2KMT2AGLATAAR1NPC1 | |
| SCHEMBL7098744 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2KMT2AGLATAAR1NPC1 | |
| SCHEMBL2746054 | 0.78 | SMN1; SMN2 (0.65) | SMN1; SMN2KMT2AGLATAAR1NPC1 | |
| SCHEMBL3657319 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2AGLATAAR1NPC1 | |
| SCHEMBL140038 | 0.76 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2AGLATAAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009079624-A1 | 4-IMIDAZOLIDINONES AS KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2009-06-25 | — | — | WO | disclosed |