Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | FPR2 | P25090 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.53 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.53 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.53 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656770 | 0.86 | SMN1; SMN2 (0.63) | SMN1; SMN2GLAKMT2ATAAR1ALDH1A1 | |
| SCHEMBL8019170 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2GLAKMT2ATAAR1ALDH1A1 | |
| SCHEMBL25344865 | 0.83 | CYP1A2 (0.54) | SMN1; SMN2TAAR1ALDH1A1NPC1GAA | |
| SCHEMBL4583404 | 0.82 | SMN1; SMN2 (0.75) | SMN1; SMN2GLAKMT2ATAAR1ALDH1A1 | |
| SCHEMBL2746054 | 0.81 | SMN1; SMN2 (0.65) | SMN1; SMN2GLAKMT2ATAAR1ALDH1A1 | |
| SCHEMBL140038 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2GLAKMT2ATAAR1ALDH1A1 | |
| SCHEMBL10266158 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2GLAKMT2ATAAR1ALDH1A1 | |
| SCHEMBL3659185 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2GLAKMT2ATAAR1ALDH1A1 | |
| SCHEMBL249713 | 0.78 | SMN1; SMN2 (0.69) | SMN1; SMN2GLAKMT2ATAAR1ALDH1A1 | |
| SCHEMBL30858767 | 0.77 | SMN1; SMN2 (0.77) | SMN1; SMN2GLAKMT2ATAAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234615-A1 | 4-IMIDAZOLIDINONES AS KV1.5 POTASSIUM CHANNEL INHIBITORS | Wyeth LLC (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079624-A1 | 4-IMIDAZOLIDINONES AS KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2009-06-25 | — | — | WO | disclosed |