Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMBR | P28336 | 3/20 | 0.71 |
| ▸ | MMP2 | P08253 | 7/20 | 0.68 |
| ▸ | MMP9 | P14780 | 7/20 | 0.68 |
| ▸ | MMP8 | P22894 | 7/20 | 0.68 |
| ▸ | IL1RN | P18510 | 3/20 | 0.67 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.67 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | MMP1 | P03956 | 2/20 | 0.65 |
| ▸ | REN | P00797 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.61 |
| ▸ | ADAM12 | O43184 | 1/20 | 0.61 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.61 |
| ▸ | MMP3 | P08254 | 1/20 | 0.61 |
| ▸ | MMP7 | P09237 | 1/20 | 0.61 |
| ▸ | MMP12 | P39900 | 1/20 | 0.61 |
| ▸ | MMP13 | P45452 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275505 | 0.93 | NMBR (0.74) | NMBRMMP2MMP9MMP8IL1RN | |
| SCHEMBL12052806 | 0.93 | NMBR (0.71) | NMBRMMP9MMP8IL1RNERAP2 | |
| SCHEMBL12052771 | 0.93 | NMBR (0.71) | NMBRMMP9MMP8IL1RNERAP2 | |
| SCHEMBL3081089 | 0.92 | NMBR (0.76) | NMBRMMP2MMP9MMP8MAPT | |
| SCHEMBL8100241 | 0.92 | IL1RN (0.70) | NMBRIL1RNERAP2ERAP1MAPT | |
| SCHEMBL11981434 | 0.91 | NMBR (0.69) | NMBRMMP2MMP9MMP8IL1RN | |
| SCHEMBL6575453 | 0.90 | MMP2 (0.72) | NMBRMMP2MMP9MMP8MAPT | |
| SCHEMBL8742461 | 0.87 | IL1RN (0.67) | NMBRMMP2MMP9MMP8IL1RN | |
| SCHEMBL4644667 | 0.87 | MMP2 (0.62) | NMBRMMP2MMP9MMP8MMP1 | |
| SCHEMBL14595064 | 0.87 | NMBR (0.74) | NMBRMMP2MMP9MMP8IL1RN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728144-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | DARWIN DISCOVERY LTD (GB) | 2000-01-19 | — | — | EP | disclosed |
| US-5853623-A | Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases | CHIROSCIENCE LIMITED (GB) | 1998-12-29 | — | — | US | disclosed |
| EP-0728144-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | Chiroscience Limited (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013289-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | CHIROSCIENCE LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |