SCHEMBL8019607

SCHEMBL8019607

CC(=O)NC(CSC[C@H]1C(=O)CC[C@@H]1COC(C)=O)C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.40
ALDH1A1 P00352 2/20 0.40
PSMB11 A5LHX3 1/20 0.34
PSMA7 O14818 1/20 0.34
PSMB1 P20618 1/20 0.34
PSMA1 P25786 1/20 0.34
PSMA2 P25787 1/20 0.34
PSMA3 P25788 1/20 0.34
PSMA4 P25789 1/20 0.34
PSMB8 P28062 1/20 0.34
PSMB9 P28065 1/20 0.34
PSMA5 P28066 1/20 0.34
PSMB4 P28070 1/20 0.34
PSMB6 P28072 1/20 0.34
PSMB5 P28074 1/20 0.34
PSMB10 P40306 1/20 0.34
PSMB3 P49720 1/20 0.34
PSMB2 P49721 1/20 0.34
PSMA6 P60900 1/20 0.34
SF3B3 Q15393 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8019620 1.00 MAPT (0.40) MAPTALDH1A1PSMB11PSMA7PSMB1
SCHEMBL8019628 1.00 MAPT (0.40) MAPTALDH1A1PSMB11PSMA7PSMB1
SCHEMBL8019971 0.87 MAPT (0.42) MAPTALDH1A1PSMB11PSMA7PSMB1
SCHEMBL8023334 0.87 MAPT (0.42) MAPTALDH1A1PSMB11PSMA7PSMB1
SCHEMBL8023327 0.87 MAPT (0.42) MAPTALDH1A1PSMB11PSMA7PSMB1
SCHEMBL6945874 0.81 MAPT (0.40) MAPTALDH1A1PSMB11PSMA7PSMB1
SCHEMBL8026507 0.81 MAPT (0.40) MAPTALDH1A1PSMB11PSMA7PSMB1
SCHEMBL6945876 0.81 MAPT (0.40) MAPTALDH1A1PSMB11PSMA7PSMB1
SCHEMBL6945871 0.81 MAPT (0.40) MAPTALDH1A1PSMB11PSMA7PSMB1
SCHEMBL8022039 0.81 MAPT (0.40) MAPTALDH1A1PSMB11PSMA7PSMB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6114364-A 2-((SUBSTITUTED)ALKYL(THIO, SULFONYL, OR SULFOXY)METHYL), 3-(CARBOXYL OR ALIPHATIC HYDROCARBONYL)CYCLOPENTAN-1-ONE DERIVATIVES, EXCEPT CYSTACYCLIN; USE AS NEURON DIFFERENTIATION ACCELERATOR NIPPON KAYAKU CO., LTD. (JP) 2000-09-05 US disclosed
EP-0976709-A1 2,3-DISUBSTITUTED CYCLOPENTANONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF NIPPON KAYAKU CO., LTD. (JP) 2000-02-02 EP disclosed