Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ICMT | O60725 | 3/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.34 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.34 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8023334 | 1.00 | MAPT (0.42) | MAPTALDH1A1ICMTSLC22A6SMN1; SMN2 | |
| SCHEMBL8019971 | 1.00 | MAPT (0.42) | MAPTALDH1A1ICMTSLC22A6SMN1; SMN2 | |
| SCHEMBL8019628 | 0.87 | MAPT (0.40) | MAPTALDH1A1ICMTSLC22A6SMN1; SMN2 | |
| SCHEMBL8019607 | 0.87 | MAPT (0.40) | MAPTALDH1A1ICMTSLC22A6SMN1; SMN2 | |
| SCHEMBL8019620 | 0.87 | MAPT (0.40) | MAPTALDH1A1ICMTSLC22A6SMN1; SMN2 | |
| SCHEMBL8026507 | 0.84 | MAPT (0.40) | MAPTALDH1A1ICMTSLC22A6SMN1; SMN2 | |
| SCHEMBL8022039 | 0.84 | MAPT (0.40) | MAPTALDH1A1ICMTSLC22A6SMN1; SMN2 | |
| SCHEMBL6945874 | 0.84 | MAPT (0.40) | MAPTALDH1A1ICMTSLC22A6SMN1; SMN2 | |
| SCHEMBL6945871 | 0.84 | MAPT (0.40) | MAPTALDH1A1ICMTSLC22A6SMN1; SMN2 | |
| SCHEMBL6945876 | 0.84 | MAPT (0.40) | MAPTALDH1A1ICMTSLC22A6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114364-A | 2-((SUBSTITUTED)ALKYL(THIO, SULFONYL, OR SULFOXY)METHYL), 3-(CARBOXYL OR ALIPHATIC HYDROCARBONYL)CYCLOPENTAN-1-ONE DERIVATIVES, EXCEPT CYSTACYCLIN; USE AS NEURON DIFFERENTIATION ACCELERATOR | NIPPON KAYAKU CO., LTD. (JP) | 2000-09-05 | — | — | US | disclosed |
| EP-0976709-A1 | 2,3-DISUBSTITUTED CYCLOPENTANONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF | NIPPON KAYAKU CO., LTD. (JP) | 2000-02-02 | — | — | EP | disclosed |