Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.45 |
| ▸ | RXRB | P28702 | 3/20 | 0.40 |
| ▸ | RARB | P10826 | 2/20 | 0.40 |
| ▸ | RARG | P13631 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 2/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.39 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8014515 | 0.76 | RXRA (0.49) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL22838113 | 0.76 | RXRA (0.47) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL14492576 | 0.76 | RXRA (0.42) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL12715260 | 0.73 | RXRA (0.43) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL14492578 | 0.73 | RXRA (0.43) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL6477255 | 0.72 | RXRA (0.42) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL17707899 | 0.72 | CA1 (0.39) | — | |
| SCHEMBL31145759 | 0.72 | RXRA (0.34) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL7218540 | 0.72 | RXRA (0.46) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL7223763 | 0.72 | RXRA (0.73) | RXRARXRBRARBRARGRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162815-A | RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |
| US-6156788-A | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-05 | — | — | US | disclosed |
| US-6015569-A | PYRIDINE OR PYRROLE DERIVATIVES OF POLYCYCLIC AROMATICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-01-18 | — | — | US | disclosed |
| US-5766610-A | USEFUL FOR TREATMENT OF MAMMALIAN SKIN AND HAIR, RHEUMATISM, RESIPIRATORY SYSTEM DISORDER, CARDIOVASCULAR AND VISION DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-06-16 | — | — | US | disclosed |
| EP-0679630-B1 | Bicyclic aromatic compounds, pharmaceutical and cosmetic compositions containing them and uses | CIRD GALDERMA (FR) | 1998-05-06 | — | — | EP | disclosed |
| EP-0679630-A1 | Bicyclic aromatic compounds, pharmaceutical and cosmetic compositions containing them and uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1995-11-02 | — | — | EP | disclosed |