Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.72 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024233 | 1.00 | OPRK1 (0.72) | OPRK1OPRM1OPRD1KMT2AMEN1 | |
| SCHEMBL8021161 | 1.00 | OPRK1 (0.72) | OPRK1OPRM1OPRD1KMT2AMEN1 | |
| SCHEMBL8018248 | 0.94 | OPRK1 (0.63) | OPRK1OPRM1OPRD1KMT2AMEN1 | |
| SCHEMBL8018252 | 0.94 | OPRK1 (0.63) | OPRK1OPRM1OPRD1KMT2AMEN1 | |
| SCHEMBL8019654 | 0.94 | OPRK1 (0.63) | OPRK1OPRM1OPRD1KMT2AMEN1 | |
| SCHEMBL8017432 | 0.93 | OPRK1 (0.76) | OPRK1OPRM1OPRD1KMT2AMEN1 | |
| SCHEMBL8024577 | 0.93 | OPRK1 (0.76) | OPRK1OPRM1OPRD1KMT2AMEN1 | |
| SCHEMBL8017436 | 0.93 | OPRK1 (0.76) | OPRK1OPRM1OPRD1KMT2AMEN1 | |
| SCHEMBL8017748 | 0.92 | OPRK1 (0.68) | OPRK1OPRM1OPRD1KMT2AMEN1 | |
| SCHEMBL8024574 | 0.92 | OPRK1 (0.68) | OPRK1OPRM1OPRD1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114381-A | TO CONTROL BRAIN DAMAGE ASSOCIATED WITH ANOXIA OR ISCHEMIA WHICH TYPICALLY FOLLOWS STROKE, CARDIAC ARREST OR PERINATAL ASPHYXIA; COMPOUND IS AN ANTAGONIST TO INHIBIT EXCITOTOXIC ACTIONS AT EXCITATORY AMINO ACID RECEPTOR SITES | G. D. SEARLE & CO. (US) | 2000-09-05 | — | — | US | disclosed |