Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.48 |
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8010798 | 0.88 | HPGD (0.53) | DYRK1AMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9374477 | 0.85 | DYRK1A (0.56) | DYRK1AMAPTSMN1; SMN2EDNRAPPARG | |
| SCHEMBL8023446 | 0.83 | NMT1 (0.48) | MAPTMEN1HSP90AA1KMT2AGABRA1 | |
| SCHEMBL23474866 | 0.83 | DYRK1A (0.54) | DYRK1AMAPTSMN1; SMN2EDNRAPPARG | |
| SCHEMBL8021827 | 0.81 | KMT2A (0.45) | MAPTMEN1HSP90AA1KMT2AGABRA1 | |
| SCHEMBL15465845 | 0.81 | EDNRA (0.59) | DYRK1AMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8024886 | 0.80 | MMP13 (0.48) | DYRK1AMAPTKMT2AGABRA1GABRG2 | |
| SCHEMBL20747928 | 0.80 | DYRK1A (0.49) | DYRK1AMAPTSMN1; SMN2EDNRAPPARG | |
| SCHEMBL8010924 | 0.78 | MCL1 (0.52) | MAPTSMN1; SMN2MEN1KMT2APPARG | |
| SCHEMBL8010663 | 0.78 | BCL2L1 (0.67) | MAPTSMN1; SMN2PPARGALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040309-A | ACTIVE MATERIAL TREATING OF RESTENOSIS, RENAL FAILURE, PULMONARY HYPERTENSION, BENIGN PROSTATIC HYPERTROPHY, MALE ERECTILE DYSFUNCTION, CONGESTIVE HEART FAILURE, STROKE, ANGINA, ATHEROSCLEROSIS, CEREBRAL AND CARDIAC ISCHAEMIA | PFIZER, INC. (US) | 2000-03-21 | — | — | US | disclosed |
| EP-0921124-A1 | Benzothiophene derivatives useful in therapy | Pfizer Limited (GB) | 1999-06-09 | — | — | EP | disclosed |