Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.32 |
| ▸ | DRD1 | P21728 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | DRD5 | P21918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3308280 | 0.79 | MAOA (0.44) | MAOAASIC3DRD2KDM4EALDH1A1 | |
| SCHEMBL3308275 | 0.79 | MAOA (0.44) | MAOAASIC3DRD2KDM4EALDH1A1 | |
| SCHEMBL13560091 | 0.78 | DRD1 (0.35) | DRD2DRD1CYP2D6HSD17B10DRD5 | |
| SCHEMBL3308910 | 0.74 | MAOA (0.43) | MAOAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL3308872 | 0.74 | MAOA (0.43) | MAOAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL4428221 | 0.71 | MAOA (0.40) | MAOAALDH1A1 | |
| SCHEMBL13845087 | 0.71 | HTR2A (0.30) | — | |
| SCHEMBL13372899 | 0.69 | MAOA (0.39) | MAOADRD2DRD1ALDH1A1HPGD | |
| SCHEMBL8032028 | 0.68 | MAOA (0.64) | MAOADRD2DRD1KDM4EALDH1A1 | |
| SCHEMBL3303648 | 0.68 | MAOA (0.42) | MAOADRD2DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |