Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 13/20 | 0.69 |
| ▸ | HTR2A | P28223 | 3/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021697 | 0.95 | MTNR1A (0.71) | MTNR1AHTR2AMTNR1BHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL8571210 | 0.94 | MTNR1A (0.69) | MTNR1AHTR2AMTNR1BHTR2CHTR2B | |
| SCHEMBL124465 | 0.89 | HTR2A (0.68) | MTNR1AHTR2AMTNR1BHTR2CHTR2B | |
| SCHEMBL29594789 | 0.89 | HTR2A (0.68) | MTNR1AHTR2AMTNR1BHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL29421606 | 0.88 | HTR2A (0.67) | MTNR1AHTR2AMTNR1BHTR2CHTR2B | |
| Bromide SCHEMBL15661932 | 0.88 | HTR2A (0.67) | MTNR1AHTR2AMTNR1BHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL577758 | 0.88 | HTR2A (0.67) | MTNR1AHTR2AMTNR1BHTR2CHTR2B | |
| Carbon Dioxide SCHEMBL14861874 | 0.84 | MTNR1A (0.65) | MTNR1AHTR2AMTNR1BHTR2CHTR2B | |
| SCHEMBL8012835 | 0.84 | MTNR1A (0.71) | MTNR1AHTR2AMTNR1BHTR2CHTR2B | |
| SCHEMBL29032209 | 0.84 | HTR2A (0.65) | MTNR1AHTR2AMTNR1BHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322508-B1 | PROCESS FOR THE MANUFACTURE OF AGOMELATINE AND ITS INTERMEDIATE | NHWA PHARMA CORP (CN) | 2013-01-02 | — | — | EP | claimed |
| EP-0745586-B1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-08 | — | — | EP | disclosed |
| US-5760071-A | AN UREA OR THIOUREA COMPOUNDS FOR TREATING MELATONINERGIC SYSTEM DISORDER, SLEEP DISORDER | ADIR ET COMPAGNIE (FR) | 1998-06-02 | — | — | US | disclosed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | disclosed |
| EP-0745586-A1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |