SCHEMBL8021835

SCHEMBL8021835

CCCCC[SiH]1CCC([C@H]2CC[C@H](c3cc(F)c(-c4ccc(F)cc4)c(F)c3)CC2)CC1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GCGR P47871 9/20 0.32
PTGS1 P23219 2/20 0.31
PTGS2 P35354 2/20 0.31
RIPK3 Q9Y572 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8021838 1.00 GCGR (0.32) GCGRPTGS1PTGS2RIPK3
SCHEMBL8396979 0.93 GCGR (0.34) GCGRRIPK3
SCHEMBL8396976 0.93 GCGR (0.34) GCGRRIPK3
SCHEMBL7757245 0.90 GCGR (0.36) GCGR
SCHEMBL7757242 0.90 GCGR (0.36) GCGR
SCHEMBL8014822 0.88 FASN (0.35) GCGR
SCHEMBL8014821 0.88 FASN (0.35) GCGR
SCHEMBL8040074 0.86 SPHK1 (0.40)
SCHEMBL8399177 0.86 SPHK1 (0.40)
SCHEMBL8399171 0.86 SPHK1 (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0670322-B1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHINETSU CHEMICAL CO (JP) 2000-01-19 EP disclosed
US-5582764-A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-12-10 US disclosed
EP-0670322-A1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it Shin-Etsu Chemical Co., Ltd. (JP) 1995-09-06 EP disclosed