Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL27600998 | 1.00 | TDP1 (0.42) | TDP1TSHRALDH1A1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL30893859 | 1.00 | TDP1 (0.42) | TDP1TSHRALDH1A1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL1436671 | 1.00 | — | — | |
| Methacrylic Acid SCHEMBL28224046 | 1.00 | TDP1 (0.42) | TDP1TSHRALDH1A1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL29565649 | 1.00 | TDP1 (0.42) | TDP1TSHRALDH1A1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL27600996 | 0.97 | TDP1 (0.40) | TDP1TSHRALDH1A1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL27547320 | 0.97 | FFAR3 (0.44) | TDP1TSHRALDH1A1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL27583557 | 0.97 | TDP1 (0.40) | TDP1TSHRALDH1A1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL8071342 | 0.97 | TDP1 (0.40) | TDP1TSHRALDH1A1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL7648519 | 0.94 | TDP1 (0.38) | TDP1TSHRALDH1A1TGFBR1FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117209775-A | Organosilicon block copolymer, preparation method thereof and deepening agent | 杭州传化精细化工有限公司 | 2023-12-12 | — | — | CN | claimed |
| CN-117209775-A | Organosilicon block copolymer, preparation method thereof and deepening agent | 杭州传化精细化工有限公司 | 2023-12-12 | — | — | CN | disclosed |
| US-20230330956-A1 | PREPARATION METHOD OF PTFE-BASED NANO FUNCTIONAL COMPOSITE MEMBRANE AND USE | CHINA THREE GORGES CORPORATION (CN) | 2023-10-19 | — | — | US | disclosed |
| CN-113224217-A | Composite film for LED wafer level packaging | 达迈科技股份有限公司 | 2021-08-06 | — | — | CN | disclosed |
| EP-3152240-B1 | PHOTOPOLYMERIZABLE COMPOSITION, PHOTOPOLYMERIZABLE INK, COMPOSITION CONTAINER, IMAGE OR CURED PRODUCT FORMING METHOD, IMAGE OR CURED PRODUCT FORMING DEVICE, AND IMAGE OR CURED PRODUCT | RICOH CO LTD (JP) | 2020-04-01 | — | — | EP | disclosed |
| EP-3365405-A1 | ANAEROBICALLY CURABLE COMPOSITIONS | Henkel IP & Holding GmbH (DE) | 2018-08-29 | — | — | EP | disclosed |
| WO-2017068196-A1 | ANAEROBICALLY CURABLE COMPOSITIONS | Henkel IP & Holding GmbH (DE) | 2017-04-27 | — | — | WO | disclosed |
| WO-2000045777-A1 | COMPOSITION, KIT, METHOD AND DEVICE FOR HAIR TREATMENT | DIJK EDDY VAN (BE) | 2000-08-10 | — | — | WO | disclosed |
| US-5240835-A | Reacting unsaturated ester with a polyol in presence of biocatalyst derived from Corynebacterium oxydans | GENENCOR INTERNATIONAL, INC. (US) | 1993-08-31 | — | — | US | disclosed |
| EP-0250427-B1 | CLEANING AND/OR DISINFECTION OF CONTACT LENSES | UNIVERSITY OF BATH (GB) | 1990-10-17 | — | — | EP | disclosed |
| US-4281991-A | Dental prostheses | PERDENT, GMBH (LI) | 1981-08-04 | — | — | US | disclosed |
| US-4267097-A | COMPRISING A MIXTURE OF ACRYLIC-TYPE MONOMERS WITH INORGANIC FILLER AND ADDITION POLYMERS | PERDENT, GMBH. (LI) | 1981-05-12 | — | — | US | disclosed |