Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.75 |
| ▸ | ESR1 | P03372 | 2/20 | 0.65 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.62 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.62 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.62 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15481630 | 0.95 | PTGS2 (0.70) | PTGS2ESR1ESR2KMT2AMEN1 | |
| SCHEMBL8011006 | 0.95 | ESR1 (0.72) | PTGS2ESR1ESR2KMT2AMEN1 | |
| SCHEMBL8022202 | 0.95 | PTGS2 (0.69) | PTGS2ESR1ESR2KMT2AMEN1 | |
| SCHEMBL15481633 | 0.91 | AOC3 (0.71) | PTGS2ESR1ESR2KMT2AMEN1 | |
| SCHEMBL8011388 | 0.89 | TP53 (0.66) | PTGS2ESR1ESR2KMT2AMEN1 | |
| SCHEMBL804992 | 0.86 | ESR2 (0.73) | PTGS2ESR1ESR2KMT2AMEN1 | |
| SCHEMBL13231714 | 0.85 | ESR2 (0.67) | PTGS2ESR1ESR2KMT2AMEN1 | |
| SCHEMBL16692234 | 0.84 | ESR2 (0.71) | PTGS2ESR1ESR2KMT2AMEN1 | |
| SCHEMBL10041513 | 0.84 | ESR2 (0.71) | PTGS2ESR1ESR2KMT2AMEN1 | |
| SCHEMBL6440249 | 0.83 | ESR2 (0.91) | PTGS2ESR1ESR2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030992-A | ANTAGONISTS FOR THE BINDING OF NEUROKININ-2 RECEPTOR; SLEEP DISORDERS; BENZIMIDES, 2- OR 3-ALKOXYBENZIMIDES AND 2,3-DIALKOXYBENZIMIDES | ELI LILLY AND COMPANY (US) | 2000-02-29 | — | — | US | disclosed |
| US-6025379-A | A SUBSTITUTED BENZIMIDAZOLE, TACHYKININ RECEPTOR ANTAGONISTS, | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| WO-1997031635-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |
| US-5552426-A | NERVOUS SYSTEM DISORDERS USING IMIDAZOLE DERIVITIVES | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0694535-A1 | Non-peptidyl tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-01-31 | — | — | EP | disclosed |