Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8025229 | 1.00 | NOTUM (0.42) | NOTUMGPR3CHRNB2CHRNA4PRCP | |
| SCHEMBL8011443 | 1.00 | NOTUM (0.42) | NOTUMGPR3CHRNB2CHRNA4PRCP | |
| SCHEMBL8023208 | 1.00 | NOTUM (0.42) | NOTUMGPR3CHRNB2CHRNA4PRCP | |
| SCHEMBL8027723 | 0.79 | GPR3 (0.36) | NOTUMGPR3CHRNB2CHRNA4PRCP | |
| SCHEMBL19512601 | 0.77 | NOTUM (0.41) | NOTUMGPR3PRCPSLC6A2SLC6A4 | |
| SCHEMBL5245013 | 0.71 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8023492 | 0.71 | PRCP (0.61) | PRCPDRD2DRD4MAOAHTR1A | |
| SCHEMBL811761 | 0.71 | PRCP (0.61) | PRCPDRD2DRD4MAOAHTR1A | |
| SCHEMBL8021507 | 0.71 | PRCP (0.61) | PRCPDRD2DRD4MAOAHTR1A | |
| SCHEMBL13014907 | 0.71 | GPR3 (0.46) | GPR3PRCPSLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |