Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 9/20 | 0.76 |
| ▸ | MMP3 | P08254 | 6/20 | 0.76 |
| ▸ | MMP9 | P14780 | 5/20 | 0.76 |
| ▸ | MMP2 | P08253 | 5/20 | 0.69 |
| ▸ | MMP7 | P09237 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.46 |
| ▸ | MMP8 | P22894 | 3/20 | 0.46 |
| ▸ | MMP20 | O60882 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | MMP10 | P09238 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | MMP15 | P51511 | 1/20 | 0.46 |
| ▸ | MMP16 | P51512 | 1/20 | 0.46 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8899210 | 1.00 | MMP1 (0.76) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL8887821 | 1.00 | MMP1 (0.76) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL8190115 | 0.91 | MMP1 (0.77) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL8193036 | 0.91 | MMP1 (0.77) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL9284717 | 0.86 | MMP1 (1.00) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7405420 | 0.84 | MMP1 (0.65) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7778120 | 0.83 | MMP1 (0.65) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7771809 | 0.83 | MMP1 (0.64) | MMP1MMP3MMP9MMP2MMP7 | |
| SCHEMBL7408645 | 0.82 | MMP1 (0.62) | MMP1MMP3MMP9MMP2MMP7 | |
| Solimastat SCHEMBL8189168 | 0.82 | MMP1 (1.00) | MMP1MMP3MMP9MMP2MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003966-A1 | N-(AMINO ACID) SUBSTITUTED SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| EP-0861226-B1 | SYNTHESIS OF CARBOXYLIC ACID DERIVATIVES | BRITISH BIOTECH PHARM (GB) | 2000-02-23 | — | — | EP | disclosed |
| US-5986132-A | Synthesis of carboxylic acid derivatives | BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) | 1999-11-16 | — | — | US | disclosed |
| WO-1997003966-A1 | N-(AMINO ACID) SUBSTITUTED SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |