Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.74 |
| ▸ | MME | P08473 | 13/20 | 0.74 |
| ▸ | CPA1 | P15085 | 2/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8027141 | 0.91 | MME (0.63) | ACEMMECPA1ACE2 | |
| SCHEMBL8017170 | 0.89 | MME (0.61) | ACEMMECPA1ACE2MMP9 | |
| SCHEMBL8033727 | 0.86 | MME (0.62) | ACEMME | |
| SCHEMBL8033733 | 0.86 | MME (0.62) | ACEMME | |
| SCHEMBL8028710 | 0.86 | ACE (0.80) | ACEMMECPA1ACE2PIN1 | |
| SCHEMBL8027283 | 0.86 | MME (0.75) | ACEMMECPA1ACE2MMP9 | |
| SCHEMBL8027310 | 0.85 | MME (0.72) | ACEMMECPA1ACE2 | |
| SCHEMBL8027314 | 0.85 | MME (0.72) | ACEMMECPA1ACE2 | |
| SCHEMBL6440665 | 0.85 | MME (1.00) | ACEMMECPA1ACE2PIN1 | |
| SCHEMBL8027151 | 0.85 | MME (1.00) | ACEMMECPA1ACE2PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738711-B1 | NOVEL 1,3-DIALKYLUREA DERIVATIVE HAVING HYDROXYL GROUP | SANTEN PHARMACEUTICAL CO LTD (JP) | 2000-03-08 | — | — | EP | disclosed |
| CN-1138321-A | 1, 3-dialkyl urea derivative with hydrocarbon group | SANTAN PHARMACEUTICAL CO LTD (JP) | 1996-12-18 | — | — | CN | disclosed |
| EP-0738711-A1 | NOVEL 1,3-DIALKYLUREA DERIVATIVE HAVING HYDROXYL GROUP | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1996-10-23 | — | — | EP | disclosed |