Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 8/20 | 0.36 |
| ▸ | REN | P00797 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PEPD | P12955 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667871 | 0.87 | RAB9A (0.60) | RAB9AALDH1A1SMN1; SMN2ACEREN | |
| SCHEMBL8667874 | 0.87 | RAB9A (0.60) | RAB9AALDH1A1SMN1; SMN2ACEREN | |
| SCHEMBL10683300 | 0.87 | RAB9A (0.60) | RAB9AALDH1A1SMN1; SMN2ACEREN | |
| SCHEMBL8027266 | 0.85 | DPP4 (0.37) | RAB9ADPP4DPP8FAPDPP9 | |
| SCHEMBL7173020 | 0.83 | RAB9A (0.55) | RAB9AALDH1A1SMN1; SMN2ACEREN | |
| SCHEMBL9193401 | 0.83 | RAB9A (0.55) | RAB9AALDH1A1SMN1; SMN2ACEREN | |
| SCHEMBL7877679 | 0.79 | RAB9A (0.48) | RAB9AALDH1A1SMN1; SMN2ACEREN | |
| SCHEMBL5702051 | 0.79 | RAB9A (0.48) | RAB9AALDH1A1SMN1; SMN2ACEREN | |
| SCHEMBL5702004 | 0.79 | RAB9A (0.48) | RAB9AALDH1A1SMN1; SMN2ACEREN | |
| Proline SCHEMBL6590813 | 0.77 | HSD17B10 (0.55) | RAB9AALDH1A1SMN1; SMN2DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156889-A | Reagent useful for cleaving a protected functional group | RHODIA CHIMIE (FR) | 2000-12-05 | — | — | US | disclosed |