Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | BRS3 | P32247 | 1/20 | 0.37 |
| ▸ | STK4 | Q13043 | 1/20 | 0.36 |
| ▸ | STK3 | Q13188 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.35 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.35 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.35 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.35 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.35 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.35 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.35 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13865477 | 0.86 | PDE4D (0.55) | PDE4DPDE4BSLC6A9 | |
| SCHEMBL3466496 | 0.84 | PDE4B (0.45) | PDE4DCD274PDE4BSLC6A9 | |
| SCHEMBL3466491 | 0.84 | PDE4B (0.45) | PDE4DCD274PDE4BSLC6A9 | |
| SCHEMBL3467286 | 0.72 | PDE4D (0.56) | PDE4DPDE4BSLC6A9 | |
| SCHEMBL3465831 | 0.71 | SLC6A9 (0.46) | PDE4DPDE4BSLC6A9 | |
| SCHEMBL16044310 | 0.70 | PDE4B (0.42) | PDE4DSTK4STK3PDE4BLMNA | |
| SCHEMBL4316681 | 0.69 | PDE4D (0.47) | PDE4DSTK4STK3LRRK2PLA2G2A | |
| SCHEMBL3788986 | 0.68 | PDE4D (0.58) | PDE4DPDE4B | |
| SCHEMBL8078532 | 0.67 | STK4 (0.36) | PDE4DSTK4STK3LRRK2PDE4B | |
| SCHEMBL2927258 | 0.67 | SLC6A9 (0.37) | PDE4DPDE4BCYP3A4MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120213758-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DeCODE Genetics enf (IS) | 2012-08-23 | — | — | US | disclosed |
| WO-2009067621-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120213758-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | PDE4A, PDE4B, PDE3B | PDE4D 7/4885BRS3 895/4885STK4 1351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.