Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 11/20 | 0.50 |
| ▸ | DRD2 | P14416 | 10/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | IL6 | P05231 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8027290 | 0.96 | DRD2 (0.44) | DRD3DRD2FGFR1SRCTDP1 | |
| SCHEMBL8025592 | 0.90 | DRD2 (0.48) | DRD3DRD2TNFIL6FGFR1 | |
| SCHEMBL8011267 | 0.88 | ALOX5AP (0.39) | DRD3DRD2TDP1ACSS2BRD4 | |
| SCHEMBL8024684 | 0.87 | DRD3 (0.52) | DRD3DRD2FGFR1SRCTLR7 | |
| SCHEMBL8027305 | 0.86 | ALOX5AP (0.40) | DRD3DRD2TDP1ACSS2BRD4 | |
| SCHEMBL8024086 | 0.86 | DRD2 (0.43) | DRD3DRD2FGFR1SRCTDP1 | |
| SCHEMBL8023740 | 0.86 | DRD2 (0.46) | DRD3DRD2TNFIL6FGFR1 | |
| SCHEMBL8026804 | 0.84 | ESR1 (0.52) | DRD3DRD2 | |
| SCHEMBL8011162 | 0.84 | BRD4 (0.39) | DRD3DRD2TDP1BRD4 | |
| SCHEMBL8011191 | 0.82 | DRD3 (0.46) | DRD3DRD2FGFR1SRCACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030992-A | ANTAGONISTS FOR THE BINDING OF NEUROKININ-2 RECEPTOR; SLEEP DISORDERS; BENZIMIDES, 2- OR 3-ALKOXYBENZIMIDES AND 2,3-DIALKOXYBENZIMIDES | ELI LILLY AND COMPANY (US) | 2000-02-29 | — | — | US | disclosed |
| US-6025379-A | A SUBSTITUTED BENZIMIDAZOLE, TACHYKININ RECEPTOR ANTAGONISTS, | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| US-5552426-A | NERVOUS SYSTEM DISORDERS USING IMIDAZOLE DERIVITIVES | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0694535-A1 | Non-peptidyl tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-01-31 | — | — | EP | disclosed |