Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 3/20 | 0.64 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.43 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424817 | 0.89 | METAP1 (0.65) | METAP1ACHECYP19A1THRATHRB | |
| SCHEMBL8028175 | 0.86 | CYP19A1 (0.61) | METAP1ACHECYP19A1THRATHRB | |
| SCHEMBL3843643 | 0.85 | METAP1 (0.70) | METAP1ACHECYP19A1CYP27A1CYP24A1 | |
| SCHEMBL29130764 | 0.85 | METAP1 (0.64) | METAP1CYP19A1THRATHRBCYP27A1 | |
| SCHEMBL8874279 | 0.81 | METAP1 (0.61) | METAP1ACHECYP19A1CYP24A1 | |
| SCHEMBL29130805 | 0.80 | METAP1 (0.68) | METAP1ACHECYP19A1THRATHRB | |
| SCHEMBL8030964 | 0.80 | MEN1 (0.44) | METAP1ACHECYP19A1THRATHRB | |
| SCHEMBL30715899 | 0.80 | METAP1 (0.68) | METAP1ACHECYP19A1THRATHRB | |
| SCHEMBL27347569 | 0.80 | ACHE (0.56) | METAP1ACHETHRATHRB | |
| SCHEMBL8874562 | 0.79 | METAP1 (0.69) | METAP1ACHECYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166031-A | Substituted tetralins, chromans and related compounds in the treatment of asthma | PFIZER INC, (US) | 2000-12-26 | — | — | US | disclosed |
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |