Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.40 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DHPS | P49366 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4326850 | 0.90 | TAAR1 (0.47) | TAAR1NPC1MAPTTSHRSMN1; SMN2 | |
| SCHEMBL3467045 | 0.88 | PDE4B (0.42) | NPC1MAPTTSHRSMN1; SMN2PDE4B | |
| SCHEMBL3466371 | 0.88 | PDE4B (0.42) | NPC1MAPTTSHRSMN1; SMN2PDE4B | |
| SCHEMBL8032267 | 0.88 | TSHR (0.40) | NPC1MAPTTSHRSMN1; SMN2PDE4B | |
| SCHEMBL3465822 | 0.84 | TSHR (0.38) | NPC1MAPTTSHRSMN1; SMN2PDE4B | |
| SCHEMBL3791461 | 0.84 | PDE4D (0.44) | TAAR1NPC1MAPTTSHRSMN1; SMN2 | |
| SCHEMBL4316376 | 0.83 | PDE4B (0.45) | TAAR1NPC1MAPTTSHRSMN1; SMN2 | |
| SCHEMBL3793591 | 0.83 | CTSA (0.45) | PDE4DCD274 | |
| SCHEMBL3468023 | 0.82 | PDE4B (0.42) | TAAR1PDE4BPDE4D | |
| SCHEMBL10440610 | 0.82 | PDE4D (0.39) | TAAR1NPC1MAPTTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067621-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |