Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8028035 | 0.88 | TAAR1 (0.43) | TSHRNPC1MAPTSMN1; SMN2PDE4B | |
| SCHEMBL3466371 | 0.86 | PDE4B (0.42) | TSHRNPC1MAPTSMN1; SMN2PDE4B | |
| SCHEMBL3467045 | 0.86 | PDE4B (0.42) | TSHRNPC1MAPTSMN1; SMN2PDE4B | |
| SCHEMBL3465822 | 0.83 | TSHR (0.38) | TSHRNPC1MAPTSMN1; SMN2PDE4B | |
| SCHEMBL3793591 | 0.82 | CTSA (0.45) | PDE4DCTSA | |
| SCHEMBL4316642 | 0.82 | ESR2 (0.46) | TSHRNPC1MAPTSMN1; SMN2PDE4B | |
| SCHEMBL4326850 | 0.81 | TAAR1 (0.47) | TSHRNPC1MAPTSMN1; SMN2PDE4B | |
| SCHEMBL3467080 | 0.80 | PDE4B (0.42) | TSHRNPC1MAPTSMN1; SMN2PDE4B | |
| SCHEMBL7911734 | 0.80 | PDE4D (0.44) | MAPTPDE4BPDE4DMEN1KMT2A | |
| SCHEMBL3791461 | 0.80 | PDE4D (0.44) | TSHRNPC1MAPTSMN1; SMN2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009067621-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |