SCHEMBL8028165

SCHEMBL8028165

CCOC(=O)CCCn1c(Cc2ccc(C#N)cc2)nc2cc(NC(=O)C3(C)CCCCC3)ccc21

nearest known ligand 0.44

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 9/20 0.43
BCHE P06276 4/20 0.43
ACHE P22303 2/20 0.43
OPRM1 P35372 1/20 0.40
ITK Q08881 5/20 0.40
CNR1 P21554 4/20 0.40
USP21 Q9UK80 2/20 0.40
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8028171 0.98 CNR2 (0.44) CNR2BCHEACHEOPRM1ITK
SCHEMBL8030096 0.84 NPC1 (0.47) CNR2BCHEACHEITK
SCHEMBL8143300 0.81 F2 (0.58) CNR2BCHEITK
SCHEMBL8031600 0.78 BCHE (0.45) CNR2BCHEACHEOPRM1
SCHEMBL8026960 0.78 CNR2 (0.51) CNR2BCHEACHEITKCNR1
SCHEMBL8026066 0.78 CNR2 (0.41) CNR2BCHEITKCNR1
SCHEMBL8028272 0.78 CNR2 (0.60) CNR2BCHEACHEOPRM1ITK
SCHEMBL8026445 0.77 F2 (0.46) CNR2BCHEITKCNR1
SCHEMBL8028166 0.77 ITK (0.59) CNR2ITK
SCHEMBL8026171 0.77 NPC1 (0.47) ITK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6114532-A ANTICOAGULANT BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-09-05 US disclosed