Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19538828 | 0.81 | BRD4 (0.46) | BRD4CREBBPDGAT1CSF1RMEN1 | |
| SCHEMBL29868688 | 0.80 | BRD4 (0.46) | BRD4CREBBPDGAT1USP2PNP | |
| SCHEMBL189854 | 0.80 | BRD4 (0.46) | BRD4CREBBPDGAT1HSD17B10CSF1R | |
| SCHEMBL19531663 | 0.78 | BRD4 (0.44) | BRD4CREBBPDGAT1CSF1RNTRK1 | |
| SCHEMBL8014137 | 0.78 | BRD4 (0.44) | BRD4CREBBPDGAT1 | |
| SCHEMBL17457845 | 0.77 | BRD4 (0.44) | BRD4CREBBPDGAT1CSF1R | |
| SCHEMBL29600164 | 0.75 | BRD4 (0.43) | BRD4CREBBPDGAT1 | |
| SCHEMBL15183831 | 0.75 | BRD4 (0.43) | BRD4CREBBPDGAT1 | |
| SCHEMBL8012052 | 0.75 | BRD4 (0.41) | BRD4CREBBPDGAT1CSF1RNTRK1 | |
| SCHEMBL8012757 | 0.75 | BRD4 (0.47) | BRD4CREBBPCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110931-A | FOR PREGNANCY PROPHYLAXIS AND TREATMENT OF GLANDULAR DISORDERS, HORMONE DEFICIENCY DISORDERS, GASTROINTESTINAL DISORDERS, GROWTH DISORDERS | MERCK & CO., INC. (US) | 2000-08-29 | — | — | US | disclosed |
| US-6025366-A | Antagonists of gonadotropin releasing hormone | MERCK & CO., INC. (US) | 2000-02-15 | — | — | US | disclosed |