SCHEMBL8028402

SCHEMBL8028402

CC1CN(Cc2ccc(C(F)(F)F)cc2)[C@H](C)CN1C(c1cccc(O[Si](C)(C)C(C)(C)C)c1)c1ccccc1C#N

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
OPRD1 P41143 2/20 0.38
NR1H2 P55055 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6652254 1.00 OPRD1 (0.38) OPRD1NR1H2
SCHEMBL6654180 0.92 OPRD1 (0.39) OPRD1
SCHEMBL6923473 0.92 OPRD1 (0.44) OPRD1
SCHEMBL6653162 0.91 OPRD1 (0.44) OPRD1
SCHEMBL6653646 0.84
SCHEMBL7968538 0.82 OPRD1 (0.46) OPRD1
SCHEMBL7971321 0.77 OPRD1 (0.50) OPRD1
SCHEMBL7958113 0.77 OPRD1 (0.49) OPRD1
SCHEMBL7970995 0.76 OPRD1 (0.48) OPRD1
SCHEMBL7974732 0.76 OPRD1 (0.48) OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0983251-A1 ANTI-INFLAMMATORY PIPERAZINYL-BENZYL-TETRAZOLE DERIVATIVES AND INTERMEDIATES THEREOF Pfizer Limited (GB) 2000-03-08 EP disclosed
WO-1998052929-A1 ANTI-INFLAMMATORY PIPERAZINYL-BENZYL-TETRAZOLE DERIVATIVES AND INTERMEDIATES THEREOF PFIZER LIMITED (GB) 1998-11-26 WO disclosed