Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2620050 | 1.00 | BACE1 (0.34) | BACE1DRD2GNRHRBACE2ALDH1A1 | |
| SCHEMBL8039168 | 1.00 | BACE1 (0.34) | BACE1DRD2GNRHRBACE2ALDH1A1 | |
| SCHEMBL13009632 | 1.00 | BACE1 (0.34) | BACE1DRD2GNRHRBACE2ALDH1A1 | |
| SCHEMBL2620055 | 1.00 | BACE1 (0.34) | BACE1DRD2GNRHRBACE2ALDH1A1 | |
| SCHEMBL8031672 | 0.93 | GNRHR (0.35) | BACE1DRD2GNRHRBACE2ALDH1A1 | |
| SCHEMBL2619849 | 0.93 | GNRHR (0.35) | BACE1DRD2GNRHRBACE2ALDH1A1 | |
| SCHEMBL2619845 | 0.93 | GNRHR (0.35) | BACE1DRD2GNRHRBACE2ALDH1A1 | |
| SCHEMBL13177589 | 0.92 | BACE1 (0.34) | BACE1BACE2KCNH2 | |
| SCHEMBL2620042 | 0.92 | DRD2 (0.36) | BACE1DRD2GNRHRBACE2ALDH1A1 | |
| SCHEMBL2620033 | 0.92 | DRD2 (0.36) | BACE1DRD2GNRHRBACE2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009091016-A1 | CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-07-23 | — | — | WO | disclosed |