Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.57 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.57 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029337 | 1.00 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1ALOX5APPPARGPPARD | |
| SCHEMBL8029106 | 0.89 | CYSLTR1 (0.53) | CYSLTR2CYSLTR1ALOX5GPBAR1 | |
| SCHEMBL8029102 | 0.89 | CYSLTR1 (0.53) | CYSLTR2CYSLTR1ALOX5GPBAR1 | |
| SCHEMBL8034925 | 0.81 | ALOX5 (0.53) | CYSLTR2CYSLTR1ALOX5GPBAR1 | |
| SCHEMBL8034921 | 0.81 | ALOX5 (0.53) | CYSLTR2CYSLTR1ALOX5GPBAR1 | |
| SCHEMBL8034999 | 0.79 | ALOX5 (0.47) | CYSLTR2CYSLTR1ALOX5GPBAR1 | |
| SCHEMBL8034993 | 0.79 | ALOX5 (0.47) | CYSLTR2CYSLTR1ALOX5GPBAR1 | |
| SCHEMBL8034997 | 0.79 | ALOX5 (0.47) | CYSLTR2CYSLTR1ALOX5GPBAR1 | |
| SCHEMBL8029126 | 0.78 | ALOX5 (0.48) | CYSLTR2CYSLTR1ALOX5APALOX5GPBAR1 | |
| SCHEMBL8029128 | 0.78 | ALOX5 (0.48) | CYSLTR2CYSLTR1ALOX5APALOX5GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166031-A | Substituted tetralins, chromans and related compounds in the treatment of asthma | PFIZER INC, (US) | 2000-12-26 | — | — | US | disclosed |
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |