Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2632308 | 1.00 | BACE1 (0.44) | BACE1KCNH2CTSDBACE2NCEH1 | |
| SCHEMBL2108854 | 0.88 | BACE1 (0.44) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL13177465 | 0.87 | BACE1 (0.48) | BACE1CTSDBACE2NCEH1 | |
| SCHEMBL8034170 | 0.82 | BACE1 (0.63) | BACE1CTSDBACE2 | |
| SCHEMBL2632309 | 0.82 | BACE1 (0.63) | BACE1CTSDBACE2 | |
| SCHEMBL2929812 | 0.81 | BACE1 (0.50) | BACE1CTSDBACE2 | |
| SCHEMBL2619830 | 0.78 | BACE1 (0.47) | BACE1KCNH2BACE2 | |
| SCHEMBL2926816 | 0.78 | BACE1 (0.47) | BACE1KCNH2BACE2 | |
| SCHEMBL9913407 | 0.78 | BACE1 (0.66) | BACE1KCNH2BACE2 | |
| SCHEMBL7918276 | 0.78 | BACE1 (0.66) | BACE1KCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009091016-A1 | CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-07-23 | — | — | WO | disclosed |