Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 16/20 | 0.59 |
| ▸ | PPARA | Q07869 | 13/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968339 | 0.91 | FFAR1 (0.61) | PPARGPPARAFFAR1KDRMAPT | |
| SCHEMBL6052101 | 0.91 | PPARG (0.61) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL5080606 | 0.89 | FFAR1 (0.59) | PPARGPPARAFFAR1KDRMAPT | |
| SCHEMBL8137753 | 0.88 | PPARG (0.48) | PPARGPPARAFFAR1 | |
| SCHEMBL8341159 | 0.85 | FFAR1 (0.52) | PPARGPPARAFFAR1KDR | |
| SCHEMBL5086402 | 0.84 | PPARG (0.49) | PPARGPPARAFFAR1KDRMAPT | |
| SCHEMBL8137811 | 0.83 | KDR (0.45) | PPARGPPARAFFAR1KDRCYP3A4 | |
| SCHEMBL10682736 | 0.83 | PPARG (0.45) | PPARGPPARAFFAR1CYP3A4CYP2C9 | |
| SCHEMBL131889 | 0.83 | PPARG (0.45) | PPARGPPARAFFAR1CYP3A4CYP2C9 | |
| SCHEMBL6960218 | 0.82 | PPARG (0.57) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110951-A | LOWERING INSULIN DRUG THERAPY IN NON-OBESE, NON-DIABETIC INDIVIDUALS | BETHESDA PHARMACEUTICALS, INC. | 2000-08-29 | — | — | US | disclosed |
| US-5594015-A | Thiazolidine derivatives for the treatment of psoriasis | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-01-14 | — | — | US | disclosed |
| US-5053420-A | Antidiabetic agents | KURTZ, THEODORE W. | 1991-10-01 | — | — | US | disclosed |
| WO-1991005538-A2 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | PERSHADSINGH HARRIHAR A (US) | 1991-05-02 | — | — | WO | disclosed |
| EP-0177353-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-04-11 | — | — | EP | disclosed |
| US-4725610-A | TREATMENT OF HYPERLIPEMIA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0177353-A2 | Thiazolidinedione derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-04-09 | — | — | EP | disclosed |