Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.45 |
| ▸ | PPARA | Q07869 | 10/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365048 | 0.87 | PPARG (0.39) | PPARGPPARAFFAR1CYP2C9 | |
| SCHEMBL6052101 | 0.84 | PPARG (0.61) | PPARGPPARACYP2C9KCNH2CYP3A4 | |
| SCHEMBL8030739 | 0.83 | PPARG (0.59) | PPARGPPARAFFAR1CYP2C9KCNH2 | |
| SCHEMBL10367300 | 0.83 | PPARG (0.63) | PPARGPPARAFFAR1CYP2C9 | |
| SCHEMBL131889 | 0.81 | PPARG (0.45) | PPARGPPARAFFAR1CYP2C9KCNH2 | |
| SCHEMBL10516260 | 0.78 | TARBP2 (0.39) | PPARGPPARAPOLBTDP1FFAR1 | |
| SCHEMBL1220163 | 0.78 | PPARG (0.45) | PPARGPPARAFFAR1CYP2C9KCNH2 | |
| SCHEMBL7160529 | 0.77 | FFAR1 (0.45) | PPARGPPARAPOLBTDP1FFAR1 | |
| SCHEMBL10365841 | 0.76 | GPR35 (0.56) | PPARGPOLB | |
| SCHEMBL10365844 | 0.76 | GPR35 (0.56) | PPARGPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725610-A | TREATMENT OF HYPERLIPEMIA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0177353-A2 | Thiazolidinedione derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-04-09 | — | — | EP | disclosed |