Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858566 | 0.92 | ALDH1A1 (0.51) | APEX1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13868150 | 0.90 | PTGS1 (0.47) | APEX1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13868159 | 0.85 | APEX1 (0.48) | APEX1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13295134 | 0.84 | ALDH1A1 (0.45) | APEX1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20856994 | 0.83 | PTGS1 (0.48) | APEX1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL858563 | 0.83 | PTGS1 (0.48) | APEX1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL859188 | 0.81 | SMN1; SMN2 (0.44) | APEX1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1524585 | 0.77 | PTGS1 (0.50) | ALDH1A1MAPT | |
| SCHEMBL13157335 | 0.77 | PTGS1 (0.50) | ALDH1A1MAPT | |
| SCHEMBL1524589 | 0.77 | PTGS1 (0.50) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012454-A1 | METHODS OF TREATING METASTATIC BREAST CANCER WITH 4-IODO-3-NITROBENZAMIDE AND IRINOTECAN | BIPAR SCIENCES, INC. (US) | 2012-01-26 | — | — | WO | disclosed |
| WO-2009073869-A1 | TREATMENT OF CANCER WITH COMBINATIONS OF TOPOISOMERASE INHIBITORS AND PARP INHIBITORS | BIPAR SCIENCES, INC. (US) | 2009-06-11 | — | — | WO | disclosed |