Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 12/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5988051 | 0.79 | MTNR1A (0.56) | MTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL8030998 | 0.76 | MTNR1A (0.67) | MTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL5988698 | 0.76 | MTNR1A (0.56) | MTNR1AMTNR1BL3MBTL1HSD17B10 | |
| SCHEMBL28219034 | 0.75 | TYR (0.52) | MEN1TSHRKMT2AKDM4EALDH1A1 | |
| SCHEMBL28233273 | 0.74 | SMN1; SMN2 (0.57) | MTNR1AMTNR1BL3MBTL1HPGD | |
| SCHEMBL8526051 | 0.74 | MEN1 (0.55) | MTNR1AMTNR1BLMNABLMMEN1 | |
| SCHEMBL10110677 | 0.74 | TYR (0.54) | MEN1TSHRKMT2AKDM4EALDH1A1 | |
| SCHEMBL2543023 | 0.73 | MTNR1A (0.52) | MTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL7721087 | 0.72 | TYR (0.57) | MEN1TSHRKMT2AKDM4EALDH1A1 | |
| SCHEMBL7569666 | 0.72 | TYR (0.57) | MEN1TSHRKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745586-B1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-08 | — | — | EP | claimed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | claimed |
| EP-0745586-A1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | claimed |
| EP-0745586-B1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-08 | — | — | EP | disclosed |
| US-5760071-A | AN UREA OR THIOUREA COMPOUNDS FOR TREATING MELATONINERGIC SYSTEM DISORDER, SLEEP DISORDER | ADIR ET COMPAGNIE (FR) | 1998-06-02 | — | — | US | disclosed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | disclosed |
| EP-0745586-A1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |