Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11832981 | 0.82 | TRPV1 (0.51) | TRPV1HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL11557313 | 0.79 | TRPV1 (0.45) | TRPV1HDAC1AKR1C2MAPTKDM4E | |
| SCHEMBL11189245 | 0.78 | TRPV1 (0.45) | TRPV1HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL8122137 | 0.78 | TRPV1 (0.45) | TRPV1HDAC1AKR1C2MAPTKDM4E | |
| SCHEMBL8686345 | 0.76 | TRPV1 (0.50) | TRPV1HDAC1AKR1C2MAPTKDM4E | |
| SCHEMBL10525350 | 0.74 | TRPV1 (0.41) | TRPV1HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL10526688 | 0.74 | TRPV1 (0.41) | TRPV1HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL11212906 | 0.74 | TRPV1 (0.42) | TRPV1HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL9293018 | 0.74 | TRPV1 (0.42) | TRPV1HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL10880872 | 0.74 | TRPV1 (0.41) | TRPV1HDAC1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6075120-A | A HETERODIMERIC PEPTIDE MODULATOR; FOR THE TREATMENT OF ASTHMA; FOR THE TREATMENT OF PAIN; ANTIINFLAMMATORY AGENTS | CORTECH, INC. (US) | 2000-06-13 | — | — | US | disclosed |
| US-5863899-A | ANALGESICS AND ANTIINFLAMMATORY AGENT; A MORPHINE OR DERIVATIVE IS ATTACHED TO BRANDYKININ ANTAGONIST PEPTIDE BY MALEIMIDO OR AMINO ACID ANALOG LINKER | CORTECH, INC. (US) | 1999-01-26 | — | — | US | disclosed |
| EP-0671941-A4 | BRADYKININ ANTAGONISTS. | CORTECH INC (US) | 1996-05-29 | — | — | EP | disclosed |
| EP-0671941-A1 | BRADYKININ ANTAGONISTS | CORTECH, INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994011021-A1 | BRADYKININ ANTAGONISTS | CORTECH, INC. (US) | 1994-05-26 | — | — | WO | disclosed |