Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.33 |
| ▸ | DPP4 | P27487 | 9/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.31 |
| ▸ | FAP | Q12884 | 2/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL8032136 | 1.00 | SLC7A5 (0.39) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL18250039 | 0.97 | SLC7A5 (0.42) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL28134392 | 0.96 | SLC7A5 (0.36) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL5957028 | 0.96 | SLC7A5 (0.36) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL5957024 | 0.96 | SLC7A5 (0.36) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL27468590 | 0.94 | SLC7A5 (0.44) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL18249977 | 0.94 | SLC7A5 (0.44) | SLC7A5RENSLC1A3SLC1A2DPP4 | |
| Leucine SCHEMBL14966504 | 0.93 | SLC7A5 (0.45) | SLC7A5SLC1A3SLC1A2DPP4SLC1A1 | |
| Leucine SCHEMBL27686470 | 0.93 | SLC7A5 (0.45) | SLC7A5SLC1A3SLC1A2DPP4SLC1A1 | |
| Leucine SCHEMBL14966502 | 0.93 | SLC7A5 (0.45) | SLC7A5SLC1A3SLC1A2DPP4SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062508-A1 | ASSAYS FOR SCREENING COMPOUNDS WHICH INTERACT WITH CATION CHANNEL PROTEINS, MUTANT PROKARYOTIC CATION CHANNEL PROTEINS, AND USES THEREOF | THE ROCKEFELLER UNIVERSITY (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-1012300-A1 | HNK-1 SULFOTRANSFERASE AND METHODS OF USE THEREFOR | Acorda Therapeutics (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-0983365-A1 | ENZYME DERIVED FROM THERMOPHILIC ORGANISMS THAT FUNCTIONS AS A CHROMOSOMAL REPLICASE, AND PREPARATION AND USES THEREOF | THE ROCKEFELLER UNIVERSITY (US) | 2000-03-08 | — | — | EP | disclosed |
| WO-1999047923-A9 | ASSAYS FOR SCREENING COMPOUNDS WHICH INTERACT WITH CATION CHANNEL PROTEINS, MUTANT PROKARYOTIC CATION CHANNEL PROTEINS, AND USES THEREOF | UNIV ROCKEFELLER (US) | 2000-02-17 | — | — | WO | disclosed |
| WO-1999053074-A1 | ENZYME DERIVED FROM THERMOPHILIC ORGANISMS THAT FUNCTIONS AS A CHROMOSOMAL REPLICASE, AND PREPARATION AND USES THEREOF | THE ROCKFELLER UNIVERSITY (US) | 1999-10-21 | — | — | WO | disclosed |
| WO-1999047923-A2 | ASSAYS FOR SCREENING COMPOUNDS WHICH INTERACT WITH CATION CHANNEL PROTEINS, MUTANT PROKARYOTIC CATION CHANNEL PROTEINS, AND USES THEREOF | THE ROCKEFELLER UNIVERSITY (US) | 1999-09-23 | — | — | WO | disclosed |
| WO-1999011796-A1 | HNK-1 SULFOTRANSFERASE AND METHODS OF USE THEREFOR | ACORDA THERAPEUTICS (US) | 1999-03-11 | — | — | WO | disclosed |
| WO-1999007739-A2 | DNA ENCODING THE HUMAN SYNAPSIN III GENE AND USES THEREOF | THE ROCKEFELLER UNIVERSITY (US) | 1999-02-18 | — | — | WO | disclosed |
| WO-1998045452-A2 | ENZYME DERIVED FROM THERMOPHILIC ORGANISMS THAT FUNCTIONS AS A CHROMOSOMAL REPLICASE, AND PREPARATION AND USES THEREOF | THE ROCKFELLER UNIVERSITY (US) | 1998-10-15 | — | — | WO | disclosed |